The course will play to over 7,600 yards for this biennial event.
Tiger Woods, who headlines the United States team, was the winner of the 1999 and 2006 PGA Championships at Medinah, so he'll obviously have a good feeling about this course. His win in 1999 was the start of the "Tiger Slam."
Sergio Garcia will have those same good feeling as he finished second to Woods in 1999. The Spaniard had a memorable shot that week from against a tree, which he hit a spectacular shot, then ran up the fairway to see where the shot landed.
Woods and Luke Donald shared the lead after three rounds in 2006, but Woods closed with a 68 to win by five over Shaun Micheel. Donald struggled to a 74 to fall into a share of third with, you guessed it, Garcia.
Woods, Phil Mickelson and Jim Furyk will be the old guard on the U.S. team this week. Mickelson is making his U.S. record ninth Ryder Cup start, and those three combined have played in 24 Ryder Cups. That squad also boasts four rookies and two reigning major champions - Webb Simpson and Bubba Watson.
Brandt Snedeker, who won the Tour Championship and FedExCup, and Dustin Johnson are among the hottest American players entering the Ryder Cup.
2011 PGA Champion Keegan Bradley, 2-time winner this year Jason Dufner, 2007 Masters winner Zach Johnson, reigning Players Champion Matt Kuchar and Hyundai Tournament of Champions titlist Steve Stricker round out the U.S. team.
The U.S. won at Valhalla in 2008, but the Europeans have won four of the last five Cups overall.
The Euros will be led by world No. 1 Rory McIlroy, who won the PGA Championship, then two of the four FedExCup playoff events.
While he is the clear leader of the team, Paul Lawrie, Peter Hanson and Garcia have all won in the last six weeks. The Euros clearly have the hotter team entering the week.
Former world No. 1 Martin Kaymer might be struggling the most of any of the 24 players competing this week, but he tied for 21st and shared fifth in his last two starts, so he seems to be rounding back into form.
The European team is rounded out by Volvo World Match Play winner Nicolas Colsaerts, former world No. 1 Donald, 2010 U.S. Open victor Graeme McDowell, Spanish Open champ Francesco Molinari, Ryder Cup stalwart Ian Poulter, WGC- Cadillac Championship winner Justin Rose and Lee Westwood, who is making his eighth Ryder Cup appearance. McDowell drained the winning putt in 2010 at Celtic Manor.
Golf Channel will air the opening ceremony on Thursday, then ESPN will have all day coverage on Friday, while NBC has coverage of all the action on Saturday and Sunday.
The PGA Tour will be in Las Vegas next week for the Justin Timberlake Shriners Hospitals for Children Open, where Kevin Na won in 2010. The European Tour will be in Scotland next week for the Alfred Dunhill Links Championship, where Michael Hoey won by 2 over McIlroy last year.
CHIQUITA CLASSIC, The Club at Longview, Weddington, North Carolina - The Chiquita Classic moved from July to September this year and also shifted from Ohio to North Carolina.
The tournament is being played opposite the Ryder Cup. Former Ryder Cuppers Robert Karlsson and Chris Riley will be at The Club at Longview this week as will former Presidents Cup players Woody Austin and Chris Riley.
For the third straight week, the Web.com Tour will have its defending champion in the field. Russell Knox fired four rounds in the 60s and cruised to a 3- shot win last year at TPC River's Bend in Ohio.
Last week, Danny Lee took the lead into the final round of his title defense at the WNB Golf Classic, but he ended one shot behind Luke Guthrie, who won for the second straight week.
Lee became the fourth player in tour history to finish second in his title defense, the closest anyone has come to repeating as champion in Web.com Tour history.
Golf Channel has coverage all four days this week.
The tour heads to Maryland next week for a new event, the Neediest Kids Championship.